BDNF and NGF Gene Polymorphisms and Urine BDNF-NGF Levels in Children with Primary Monosymptomatic Nocturnal Enuresis

The pathophysiology and genetic influences in nocturnal enuresis have not been fully elucidated. Delayed neuronal maturation has been suggested as a pathogenetic mechanism in primary monosymptomatic nocturnal enuresis (PMNE). Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are neurotrophins affecting maturation of the nervous system.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research