Study links perimenopause to accelerated fat mass gains, lean mass losses

FINDINGSThe menopause transition, also known as perimenopause, is the time in a woman ’s life when hormonal changes lead to irregular menstruation, hot flashes and other symptoms leading up to menopause, when menstruation stops altogether. The researchers found that women undergoing perimenopause lost lean body mass and more than doubled their fat mass. The women’s lean and fat mass remained stable after the transition to menopause. The researchers also noted ethnic/racial differences in the impact of menopause on body composition.BACKGROUNDThe relationship between menopause and changes in body composition has not been well understood. While some smaller studies have looked at the impact of the menopause transition on body composition and weight, the Study of Women ’s Health Across the Nation provides sufficiently voluminous and detailed data to enable researchers to disentangle the effects of chronological aging and reproductive aging.METHODThe researchers examined 18 years of data from the women ’s health study, assessing women’s body composition using a model that gave them a picture of that composition from the time before and after their final menstrual period, accounting for race/ethnicity and hormone therapy.IMPACTUntil now, there was no proof that menopause leads to gains in fat mass or losses of lean mass. The study demonstrates that a simple measurement of body weight does not illustrate what is happening “under the skin.&rdq...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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AbstractIncidence of non-alcoholic fatty liver disease (NAFLD) and liver cancer are 2 –3 times higher in males than females. Hormonal mechanisms are hypothesized, with studies suggesting that oophorectomy may increase risk, but population-based evidence is limited. Thus, we conducted a study within the Clinical Practice Research Datalink, with controls matched to cases of NAFLD (n  = 10,082 cases/40,344 controls) and liver cancer (n = 767 cases/3068 controls). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Effect measure modificatio...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
This study also found that Proteus DNA, a genus with many uropathogenic species (Drzewiecka, 2016), was more prevalent in women with OAB compared to asymptomatic controls (Curtiss et al., 2017). IC A recent study by Abernethy et al. suggested that the microbiome may play a role in IC (Abernethy et al., 2017). In this study, 16S rRNA analysis determined the microbiome of catheterized urine from women (n = 40) with IC was not dominated by a single genus and was less likely to contain Lactobacillus compared to asymptomatic women. Abernethy et al. also showed that L. acidophilus was associated with less severe scores on the ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Maunil K. Desai1 and Roberta Diaz Brinton2,3* 1School of Pharmacy, University of Southern California, Los Angeles, CA, United States 2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States 3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, Ita...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusions: In postmenopausal Taiwanese women, HT may be associated with an increased risk of cardiovascular disease. Although the women in our population receiving HT were near menopausal age, their risk of cardiovascular disease was still higher than in the non-HT group.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Conclusions: Serum E2 levels may help to identify women at higher risk of fractures over the menopausal transition. However, hormone assays must be standardized across laboratories for clinical implementation and further work is needed to define E2 thresholds. PMID: 30690517 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
CONCLUSIONS: Contemporary MHT does not seem to increase the risk of biliary tract cancer. The decreased risk of gallbladder cancer may be explained by the increased use of surgery for symptomatic gallstones in MHT users. PMID: 30656997 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
With the rising prevalence of metabolic syndrome (MetS), diabetes and mortality from cardiovascular disease (CVD) have also increased [1 –3]. As people age, sex differences in the prevalence of MetS and each of its component are observed [4]. Furthermore, women after menopause have a higher prevalence of MetS compared with premenopausal women regardless of age [5]. This phenomenon is related to estrogen deficiency caused by menopau se. Thus, the alteration of metabolic homeostasis via estrogen deficiency predisposes many women to MetS [6].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
Abstract In women, body weight increases with age. Often menopausal hormone therapy (MHT) is blamed for enhancing this effect. In recent years, the debate on bioidentical MHT including micronized progesterone (MP) has increased. Among others, the question has been raised of whether MHT containing MP has an impact on body weight and glucose metabolism. Based on a systematic literature review on the impact of MHT containing MP on body weight, body mass index (BMI), and glucose metabolism, the following conclusions can be drawn: estrogens combined with MP (1) either do not change or reduce body weight in normal weigh...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0659-9928In addition to oxidative stress due to the increase of free radicals, estrogen deficiency is associated with changes in enzymatic activity, glutathione redox ratio (GSH/GSSG), and the content of oxidative markers such as malondialdehyde. Tibolone, a synthetic steroid, has been used as an elective treatment for the relief of menopausal symptoms. However, the acute effects of hormonal therapy with tibolone on metabolic parameters and oxidative stress markers associated with the first stages of estrogen deficiency are still unknown. The study aimed to evaluate if the acute ...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
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