Preeclampsia and future stroke risk in women: What NPs need to know

Abstract: Preeclampsia is a complication of pregnancy that affects approximately 4% of pregnancies. Preeclampsia is defined as new-onset hypertension after 20 weeks gestation often accompanied by new-onset proteinuria. Women who experience preeclampsia during pregnancy are at an increased risk for hypertension and stroke later in life. Healthcare providers should screen women appropriately to minimize risk.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: WOMEN'S HEALTH: DNP SPECIAL ISSUE Source Type: research

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Conclusion: Periodontal disease is significantly and positively correlated with increased risk of hypertension in Chinese population, and exact mechanisms of this association should be explored in future. Introduction Periodontal disease is a complex polymicrobial inflammation, including gingivitis and periodontitis. According to the 2015 Global Burden of Disease (GBD) study, the prevalence of severe chronic periodontitis in 2015 has reached 616 million (Kassebaum et al., 2017). In China, the periodontal disease standardized DALYs rate has risen from 24.7 in 1990 to 25.7 in 2013 according to the data from 2013 GBD ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractPregnancy can be seen as a positive time for women migraineurs because the elevated estrogen and endogenous opioid levels raise the pain threshold and the stable hormone levels, which no longer fluctuate, eliminate a major trigger factor for the attacks. In a great majority of cases, indeed, migraine symptoms spontaneously improve throughout pregnancy. Generally, migraine without aura (MO) improves better than migraine with aura (MA), which can occur ex novo in pregnancy more frequently than MO. After childbirth, the recurrence rate of migraine attacks increases, especially during the first month; breastfeeding exe...
Source: Neurological Sciences - Category: Neurology Source Type: research
We report the case of a woman with severe headache associated with visual disturbances, without hypertension or proteinuria at 32 weeks of pregnancy. MRI revealed multiple recent cerebral vascular accidents. An echocardiogram detected a papillary fibroelastoma of 5mm. Maternal fetal experts determined it safe to continue the pregnancy. Childbirth at 39 weeks was normal uneventful for the newborn and mother. In the postpartum, despite the theoretical operative indication to resect the small residual papillary fibroelastoma, the patient was followed expectantly because of the stable neuro-cardiologic state. A fibroelastoma c...
Source: Annales de Cardiologie et d'Angeiologie - Category: Cardiology Authors: Tags: Ann Cardiol Angeiol (Paris) Source Type: research
Preeclampsia is a disorder characterized by high blood pressure and often proteinuria during pregnancy. It is known that a subseptic dose of bacterial lipopolysaccharide (LPS) induces production of proinflammatory cytokines, and possibly increasing the risk for developing preeclampsia. We investigated the effects of LPS on the blood-brain barrier (BBB) integrity in pregnant rats with N(omega)-nitro-l-arginine methyl ester (L-NAME) induced preeclampsia.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
​BY GREGORY TAYLOR, DO, &SHERIF G. EL-ALAYLI, DOA 30-year-old G5P3 presented to the ED with bilateral lower-extremity edema and headache for three days. She presented one week after an uncomplicated full-term vaginal delivery with an unremarkable pregnancy course and no prior requirement for antihypertensive therapy. The headache was described as achy to sharp, with associated photophobia. She also noted occasional vaginal spotting, which was common a few weeks after delivery. She denied any chest pain, shortness of breath, nausea or vomiting, abdominal pain, or any other symptoms. She admitted to occasional mild cra...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Publication date: July 2018Source: Pregnancy Hypertension, Volume 13Author(s): Genevieve Eastabrook, Tuba Aksoy, Samantha Bedell, Debbie Penava, Barbra de VrijerAbstractPreeclampsia is a serious pregnancy condition defined as new-onset hypertension and proteinuria, commonly characterized as either early, ‘placental’, or late onset, ‘maternal’, using a cut-off of 34 weeks gestation. However, it may be more useful to differentiate between the vascular remodelling and placental invasion vs. inflammation and metabolic pathophysiology that underlie these forms of preeclampsia. Due to rising rates of ob...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: July 2017 Source:Hospital Medicine Clinics, Volume 6, Issue 3 Author(s): Christine M. CombsTeaser Preeclampsia is a multisystem disorder of new-onset hypertension in the second half of pregnancy associated with abnormalities in several organ systems. Manifestations of maternal vascular endothelial dysfunction include proteinuria, thrombocytopenia, microangiopathic hemolysis, pulmonary edema, hepatic ischemia, hypercoagulability, stroke, and seizure. Preeclampsia is common, with a worldwide prevalence of 2% to 8%, and 3% to 5% of all US pregnancies, with prevalence in primiparous pregnancies approximately...
Source: Hospital Medicine Clinics - Category: Internal Medicine Source Type: research
AbstractSTUDY QUESTIONWhat is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)?SUMMARY ANSWERSHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction (FGR).WHAT IS KNOWN ALREADYA hallmark in the pathogenesis of preeclampsia (PE) is abnormal placentation with defective remodeling o...
Source: Molecular Human Reproduction - Category: Molecular Biology Source Type: research
Preeclampsia, a common hypertensive disorder of pregnancy, contributes substantially to maternal and fetal morbidity and mortality worldwide. While the cause of preeclampsia remains debated, it is clear that there are both placental and maternal causes of preeclampsia, making it a heterogeneous disease.1 Abnormal trophoblast invasion of spiral arteries during placentation leads to placental ischemia and release of placental-derived soluble factors into the maternal circulation.2 These circulating proinflammatory and antiangiogenic factors appear to produce maternal vascular inflammation and cause endothelial dysfunction th...
Source: Neurology - Category: Neurology Authors: Tags: Stroke prevention, MRI, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research
Conclusions The biomarkers sFlt-1, PlGF and sFlt-1/PlGF ratio are strong predictors for maternal and fetal complications and pregnancy prolongation. Particularly the sFlt-1/PlGF ratio has much added value for the prediction of fetal complications and pregnancy prolongation.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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