Myostatin regulates pituitary development and hepatic igf1.

MYOSTATIN REGULATES PITUITARY DEVELOPMENT AND HEPATIC IGF1. Am J Physiol Endocrinol Metab. 2019 Mar 19;: Authors: Czaja W, Nakamura YK, Li N, Eldridge JA, DeAvila DM, Thompson TB, Rodgers BD Abstract Circulating myostatin-attenuating agents are being developed to treat muscle wasting disease despite their potential to produce serious off-target effects as myostatin/activin receptors are widely distributed among many non-muscle tissues. Our studies suggest that the myokine not only inhibits striated muscle growth, but also regulates pituitary development and growth hormone (GH) action in the liver. Using a novel myostatin null label retaining model (Jekyll mice), we determined that the heterogeneous pool of pituitary stem, transit amplifying and progenitor cells in Jekyll mice depletes more rapidly after birth than the pool in wild-type mice. This correlated with increased levels of GH, prolactin and the cells that secrete these hormones, somatotropes and lactotropes, respectively, in Jekyll pituitaries. Recombinant myostatin also stimulated GH release and gene expression in pituitary cell cultures while inhibiting prolactin release. In primary hepatocytes, recombinant myostatin blocked GH-stimulated expression of two key mediators of growth, insulin-like growth factor (IGF)1 and the acid-labile subunit, and increased expression of an inhibitor, IGF binding protein-1. The significance of these findings was demonstrated by smaller musc...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research