Citalopram Improves Obsessive-Compulsive Crossword Puzzling in Frontotemporal Dementia

Behavioral variant frontotemporal dementia (bvFTD) is characterized by severe changes in personality/behavior. Recent studies have provided evidence that a decrease in serotonin receptors and neuronal loss in the raphe nuclei play a role in the bvFTD pathology. Serotonergic antidepressants have been reported to diminish behavioral disturbances in bvFTD, particularly repetitive behaviors, disinhibition, apathy, sexually inappropriate behaviors, and hyperorality. Here, we present the case of an 80-year-old Caucasian male patient with clinically and biomarker supported bvFTD ( “probable” bvFTD; disease-specific alterations in18F-fluorodesoxyglucose positron emission tomography and magnetic resonance imaging). The patient exhibited behavioral disinhibition, apathy, a loss of empathy, perseverative behavior during testing, hyperorality, changes in diet, and executive deficits in neuropsychological testing. Remarkably, he failed in solving crosswords by systematically filling in the blanks by letters in alphabetical order (A, B, C, D, etc.), indicating obsessive-compulsive behavior. One year later, the patient visited the clinic again for a follow-up investigation. He had taken 20 mg of citalopram per day for 1 consecutive year. Remarkably, he had regained the ability to fill in crossword puzzles correctly, although the neuropsychiatric inventory showed overall only small improvement in behavioral impairment. A regimen of 20 mg citalopram per day over the course of 1 ye...
Source: Case Reports in Neurology - Category: Neurology Source Type: research

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Authors: Berardelli I, Belvisi D, Pasquini M, Fabbrini A, Petrini F, Fabbrini G Abstract Introduction: reviewed studies that assessed the treatment of psychiatric disturbances in Parkinson's disease and atypical parkinsonisms. Neuropsychiatric disturbances in these conditions are frequent and have a profound impact on quality of life of patients and of their caregivers. It is therefore important to be familiar with the appropriate pharmacological and non-pharmacological interventions for treating these disorders. Areas covered: The authors searched for papers in English in Pubmed using the following keywords: Parkinso...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Conclusions: Interhemispheric functional coordination abnormalities may be one of the important pathophysiological mechanisms of OCD.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions The treatment used for PD, particularly DA, is associated with the development of ICDs and related behaviors. Susceptibility to these disorders depends on the associated risk factors. ICDs can have serious personal, family, psychosocial, financial, and medical consequences. However, in contrast, artistic activities have been described in patients with PD while undergoing treatment with DA. These patients are compulsive but report a positive influence on quality of life. These findings highlight the need for a very critical approach at the moment of Dopaminergic Replacement therapy choice. Author Contributio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: The current study reveals two PD symptoms associated with SLC6A4 polymorphisms, and provides new insight into how serotonergic system genetically participates in the symptomatic progression of PD. Further study is warranted in additional populations. Introduction Parkinson's disease (PD) is a common neurodegenerative disease with bradykinesia, rigidity, and rest tremor as its cardinal motor manifestations (1). Non-motor symptoms such as depression, cognitive problems, sleep disorders, and gastrointestinal disturbance have a great impact on life quality in PD patients (2, 3), and are usually pres...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Dondé C, Lepetit A, Dorey JM, Herrmann M PMID: 30665687 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
‘Compulsive hoarding’, defined as excessive collecting and saving behavior, results in cluttered living spaces and significant distress or impairment.1 Its current synonymy with Obsessive Compulsive Personality Disorder (OCPD) and Obsessive Compulsive Disorder (OCD) has evolved through DSM editi ons. However, hoarding behavior is not limited to OCD. Patients with hoarding behavior have been shown to meet criteria for other Axis I disorders2 including major depressive disorder,3 anorexia nervosa,4 schizophrenia,5 dementia,6 which can additionally lead to self-neglect.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Brief Report Source Type: research
CONCLUSIONS:: These findings suggest that the repetitive behaviors in bvFTD are repetitive impulsions, possibly from specific involvement of frontostriatal-anterior temporal pathology. PMID: 30537913 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
This article reviews the literature on the pharmacotherapy of psychiatric conditions co-occurring with DS, including major depressive disorder (MDD), bipolar disorder, anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), psychosis, and catatonia. A section on the phenomenon of regression is included. Expert opinion: For MDD, we typically begin with selective serotonin reuptake inhibitors (SSRIs). For bipolar disorder, we often use carbamazepine. For psychotic symptoms, we begin with risperidone or aripiprazole. We use buspirone to treat anx...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
During the past two decades, deep brain stimulation (DBS) has been recognized as an efficient therapy that alleviates the symptoms of various treatment-resistant movement disorders such as Parkinson ’s disease (PD), dystonia, and tremor (Lyons, 2011; Vidailhet et al., 2013; Aviles-Olmos et al., 2014; Fasano et al., 2014; Kalia et al., 2013; Larson, 2014). Recent reports suggest that DBS can also be effective for treating psychiatric disorders such as depression, obsessive-compulsive disorder, Tourette’s syndrome (Holtzheimer and Mayberg, 2011) as well as dementia-related disorders and Alzheimer’s disease ...
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
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