Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism

Conclusion: The rate of SAEs associated with (not necessarily caused by) diazoxide has been demonstrated. The rate of SAE in newborns with perinatal stress hyperinsulinism is significantly higher than that of otherwise healthy babies with genetic forms of hyperinsulinism, suggesting that caution should be used when prescribing diazoxide to this population. This information should help balance the risk benefit of treatment and provide guidance on screening for these complications in the population of treated patients.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research