Epigenetic regulation by endogenous metabolite pharmacology.
Epigenetic regulation by endogenous metabolite pharmacology.
Curr Opin Chem Biol. 2019 Mar 15;51:30-39
Authors: Kulkarni RA, Montgomery DC, Meier JL
Abstract
Altered metabolite levels can drive epigenetic changes critical to development and disease. However, in many cases the specific protein-metabolite interactions that underlie this process remain enigmatic. In this review, we make the case that this fundamental missing information may be discovered by applying the tools of modern drug target validation to study endogenous metabolite pharmacology. We detail examples in which chemical proteomics has been applied to gain new insights into reversible and covalent metabolite signaling mechanisms, using acetyl-CoA and fumarate as case studies. Finally, we provide a brief survey of nascent chemical biology methods whose application to the study of endogenous metabolite pharmacology may further advance the field.
PMID: 30884380 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Kulkarni RA, Montgomery DC, Meier JL Tags: Curr Opin Chem Biol Source Type: research