Sage gets U.S. approval for first postpartum depression therapy

The U.S. Food and Drug Administration on Tuesday approved Sage Therapeutics Inc's drug for postpartum depression, marking the first approval of a treatment specifically developed for the condition that affects a new mother's ability to care for herself or her baby.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Publication date: Available online 17 October 2019Source: Stem Cell ReportsAuthor(s): Yaming Yang, Ruiguo Chen, Xianming Wu, Yannan Zhao, Yongheng Fan, Zhifeng Xiao, Jin Han, Le Sun, Xiaoqun Wang, Jianwu DaiSummaryRecent studies have demonstrated that human astrocytes and fibroblasts can be directly converted into functional neurons by small molecules. However, fibroblasts, as a potentially better cell resource for transplantation, are not as easy to reprogram as astrocytes regarding their fate to neurons, and chemically induced neurons (iNs) with low efficiency from fibroblasts resulted in limited application for the trea...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: November 2019Source: The Lancet Psychiatry, Volume 6, Issue 11Author(s): Verinder Sharma, Christine Baczynski
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Authors: Pierce M, Hope HF, Kolade A, Gellatly J, Osam CS, Perchard R, Kosidou K, Dalman C, Morgan V, Di Prinzio P, Abel KM Abstract BACKGROUND: Children of parents with mental disorder face multiple challenges. AIMS: To summarise evidence about parental mental disorder and child physical health. METHOD: We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood, anxiety, obsessive-compulsive, post-traumatic stress and eating) and offspring physical health. Studies were excluded if: they reported perinatal outcomes only (
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
ConclusionsEthnicity, birthplace, discipline, and maternal educational level were major determinants of mental health status among health sciences students. Further research should be undertaken to determine the prevalence of psychological disorders using more reliable diagnostic interview.
Source: Academic Psychiatry - Category: Psychiatry Source Type: research
AbstractThis paper examines the relationship between maternal psychological well-being and specific outcomes amongst children and adolescents in Peru. First, it assesses the impacts of maternal depression and life satisfaction on health and life satisfaction of children. Then, it evaluates the impacts of maternal psychological well-being on adolescent risk behavior. Prior research focuses predominately on effects in developed country contexts, but this paper aims to shed light on the impacts in an impoverished setting. Using panel data from the Young Lives Survey, the author finds that children ’s self-reported life ...
Source: Applied Research in Quality of Life - Category: International Medicine & Public Health Source Type: research
Condition:   Post Partum Depression Intervention:   Behavioral: Cooperative Education Program based on Precede-Proceed Model Sponsor:   Gonabad University of Medical Sciences Recruiting
Source: - Category: Research Source Type: clinical trials
(CNN) — Moms-to-be who undergo physical or mental stress during their pregnancies are less likely to have a boy and may also have a higher risk of preterm birth, according to a study published Monday. “The womb is an influential first home,” said lead author Catherine Monk, director of women’s mental health in OB/GYN at NewYork-Presbyterian/Columbia University Irving Medical Center. “We do know that males are more vulnerable in utero, and presumably the stress in these women is of a long-standing nature,” Monk said. Nature typically assures there are an average of 105 boys born for every...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Pregnancy Stress Source Type: news
BACKGROUND: Postnatal depressive symptoms measured by the Edinburgh Postnatal Depression Scale (EPDS) are reported to display measurement variance regarding factor structure and the frequency of specific depressive symptoms. However, postnatal depressive s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Publication date: Available online 15 October 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Yvonne A. Dzal, Ryan J. Sprenger, William K. MilsomAbstractIn rodents, the ventilatory responses to hypoxia (low O2) and hypercarbia (high CO2) change significantly over postnatal development. In hypoxia, most adult rodents increase ventilation and decrease metabolism to some degree. Hypercarbia, however, leads to an increase in ventilation with little, to no change in metabolism. Neonates, on the other hand, respond to hypoxia with a profound metabolic depression, and a severely attenuated ventilatory response. In ...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
While maternal mental health is an important influence on child development, the existing literature focuses primarily on negative aspects of maternal mental health, particularly symptoms of depression, anxiety, or states of distress. We provide a review of the evidence on the potential importance of positive mental health for both mother and child. The evidence suggests that positive mental health is a distinct construct that associates with improved birth outcomes and potentially with specific forms of parenting that promote both academic achievement and socio-emotional function.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research
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