Long Noncoding RNA-CERNA1 Stabilized Atherosclerotic Plaques in apolipoprotein E −/− Mice

In this study, in order to investigate how a new lncRNA, CERNA1, regulates the composition of atherosclerotic plaques, we overexpressed CERNA1 inapolipoprotein E−/− (Apo E−/−) mice and analyzed the role of CERNA1 in atherosclerotic plaque stabilization. The results showed that CERNA1 inhibited the apoptosis of VSMCs and anti-inflammatory macrophages through increasing API5 level and further stabilized the atherosclerotic plaques. This discovery provided a novel therapeutic target for atherosclerosis.
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research