Capitalizing on Cancer Replication Stress by Preventing PAR Chain Turnover: A New Type of Synthetic Lethality

Publication date: 18 March 2019Source: Cancer Cell, Volume 35, Issue 3Author(s): Niamh McDermott, Erika S. Buechelmaier, Simon N. PowellTumors resistant to PARP inhibitors frequently show signs of replication stress, with hyper-activated PARP. In this issue of Cancer Cell, Pillay et al. demonstrate that inhibiting PAR-chain turnover results in cell-cycle arrest, which is cytotoxic when combined with cell-cycle checkpoint inhibition and constitutes a novel cancer therapy.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research