Assessment of sperm PAWP expression in infertile men.

Assessment of sperm PAWP expression in infertile men. Urol J. 2019 Mar 18;: Authors: Tanhaei S, Abdali-Mashhadi S, Tavalaee M, Javadian-Elyaderani S, Ghaedi K, Seifati SM, Nasr-Esfahani MH Abstract PURPOSE: The aim of this study was to evaluate expression of Post-Acrosomal WW Binding Protein (PAWP) in infertile men with low and high fertilization post ICSI and also globozoospermic men. MATERIALS AND METHODS: Semen samples were collected from 18 infertile men with previous failed or low fertilization (50%) post ICSI, 15 globozoospermic men, and 21 fertile individuals. Then, expression of PAWP was assessed at RNA with quantitative Real Time PCR. RESULTS: Relative expression of PAWP in sperm was significantly (p
Source: Urology Journal - Category: Urology & Nephrology Authors: Tags: Urol J Source Type: research

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Publication date: May 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 5Author(s): Lien M. Davidson, Yaqiong Liu, Tracey Griffiths, Celine Jones, Kevin CowardAbstractTo improve success rates, assisted reproductive technology (ART) procedures continually undergo optimization and enhancement such that the best quality gametes and embryos can be identified and manipulated, thus improving clinical outcomes. Laser technology is now being applied across ART to reduce procedure times and increase the consistency and reproducibility of traditional ART techniques such as assisted hatching, embryo biopsy, intracytoplasm...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Conclusion The periconceptional environment and lifestyle factors modify sperm epigenome. This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. In long term, metabolic disorders have been described in...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Authors: Lopes LS, Esteves SC Abstract In recent years, growing evidence has challenged the notion that sperm quantity and quality are not essential for the success of assisted reproductive technology. DNA fragmentation assessments on ejaculated and testicular sperm harvested from non-azoospermic infertile men have reported a remarkable decrease in DNA damage in spermatozoa directly retrieved from the seminiferous tubules. Moreover, emerging evidence using molecular genetic techniques indicates that aneuploidy rates are lower in testicular sperm than in ejaculated counterparts. The use of testicular sperm from non-...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Michael Grynberg1,2,3,4* and Julie Labrosse2 1AP-HP, Department of Reproductive Medicine &Fertility Preservation, Hôpital Antoine Béclère, Clamart, France 2AP-HP, Department of Reproductive Medicine &Fertility Preservation, Hôpital Jean Verdier, Bondy, France 3INSERM U1185, University Paris-Sud, Le Kremlin-Bicêtre, France 4INSERM U1133, University Paris Diderot, Paris, France The management of low prognosis patients in ART represents a challenge for reproductive specialists. Different profiles and biologic characteristics have been identified among these patients. Indeed...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conditions:   Infertility;   IVF;   ICSI;   Cryopreservation Interventions:   Procedure: Priority to freeze;   Procedure: Fresh embryo transfer Sponsor:   Tanta University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Jie Cai1†, Yi Zhang1†, Yuying Wang1, Shengxian Li1, Lihua Wang1, Jun Zheng1, Yihong Jiang1, Ying Dong1, Huan Zhou1, Yaomin Hu1, Jing Ma1, Wei Liu1,2*† and Tao Tao1*† 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China 2Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China Background: Infertility and dyslipidemia are frequently present in both women...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 6 April 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Lasse Bøllehuus Hansen, Mette Lorenzen, Ursula Bentin-Ley, John Erik Nielsen, Hans Krog, Anders Hayden Berg, Bonnie Sofie Håkansson, Astrid Munk Pedersen, Thomas Høst, Anders Juul, Martin Blomberg JensenAbstractMale fertility is routinely evaluated by semen analysis, although semen quality variables such as; sperm count, motility and morphology have low predictive value for spontaneous pregnancies and fertility treatment outcomes. Vitamin D has been suggested to be beneficial for ma...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Spermatogenesis is a complex process requiring the proper functioning of thousands of genes combined with the correct balance of hormones, temperature, and other environmental factors. Sperm isolated from the testicle, however, are generally immotile and immature —incapable of fertilizing an egg on their own, although they can be used for intracytoplasmic sperm injection. Sperm mature during transit through the epididymis, where morphologic, chemical, and other changes occur, giving them capacity for fertilization.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
CONCLUSION: The fastest clinical pregancy declining age is ranged between 25 and 32, and female infertility type is evidenced as another key predictive factor for the cumulative outcome of ART. PMID: 30947663 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research
Infertility affects approximately 11% of couples in the United States (1). Infertility treatment has been linked to hypertensive disorders of pregnancy including pre-eclampsia, a leading cause of maternal and fetal morbidity worldwide (2, 3). Infertility status and infertility treatment may function independently as risk factors for hypertensive disorders of pregnancy (3). Most of this risk may be due to the higher frequency of multifetal gestation; however, risk remains increased even in singleton gestations for those undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI; 4,5).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster Presentation Source Type: research
More News: ICSI (Intracytoplasmic Sperm Injection) | Infertility | Reproduction Medicine | Study | Urology & Nephrology