The Latest on Vaccinations, Leprosy & Lyme Disease

CHICAGO—Keith Winthrop, MD, MPH, professor of public health and preventive medicine at the Oregon Health &Science University School of Medicine, Portland, Ore., began the vaccination session at the 2018 ACR/ARHP Annual Meeting with a review of vaccination timing and targets. He presented a clinically relevant snapshot of the vaccines rheumatologists should consider and emphasized... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Meeting Reports 2018 ACR/ARHP Annual Meeting leprosy Lyme Disease vaccination Source Type: research

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Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 145 Author(s): Istvan Katona, Joachim Weis This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders,...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
ConclusionsAutonomic dysfunction may be responsible for additional morbidity in some infectious diseases.
Source: Clinical Autonomic Research - Category: Research Source Type: research
Conclusions:There was no report describing CIDP related to leprosy reverse reaction in the literature. This case could be attributed to cell injury caused by type 1reaction that exposed the neural antigens and incited an autoimmune reaction.Disclosure: Dr. Andrade has nothing to disclose. Dr. Vital has nothing to disclose. Dr. Pitta has nothing to disclose. Dr. Silveira has nothing to disclose. Dr. Giesel has nothing to disclose. Dr. Olmo has nothing to disclose. Dr. Sarno has nothing to disclose. Dr. Jardim has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Conclusions:Together, our results suggest that understanding the regulatory pathways associated with IL-6 could be an interesting lead to novel therapeutic strategies for neuropathic pain in leprosy patients.Disclosure: Dr. Jardim has nothing to disclose. Dr. Silveira has nothing to disclose. Dr. Pitta has nothing to disclose. Dr. Giesel has nothing to disclose. Dr. Andrade has nothing to disclose. Dr. Vital has nothing to disclose. Dr. Sarno has nothing to disclose. Dr. Olmo has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Conclusions:Knowledge of NP characteristics could be used to develop more effective therapeutic approaches for a pain condition that is notoriously difficult to treat.Disclosure: Dr. Giesel has nothing to disclose. Dr. Pitta has nothing to disclose. Dr. Silveira has nothing to disclose. Dr. Andrade has nothing to disclose. Dr. Vital has nothing to disclose. Dr. Sarno has nothing to disclose. Dr. Jardim has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Conclusions:Silent neuritis should be recognized early to prevent leprosy disability, and it is based on clinical parameters. NCS is a sensitive tool to study leprous nerve damage. It can provide information concerning clinically undetected alterations. Most recent studies have conveyed the idea that early electrophysiological changes of leprosy patients are discordant from the initiation and type of the predominant injury, which is considered by most authors as demyelination. If treatment with corticosteroids is indicated to prevent further disability in these cases is a question that remains to be answered. A better comp...
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
This study evaluated antibiotic vs placebo. The study was terminated early due to the determined likelihood that a beneficial effect would not be found. When this was critically analyzed with biostatistical methods, an article was published which I believe demonstrates that Klempner's study was so poorly designed and analyzed that in order for a treatment effect to have been observed, the antibiotic treated patients would have had to improve to a level of health which was a full standard deviation better than the average health of the general population. It's a reasonable hope for antibiotics to return a patient to a somew...
Source: Science - The Huffington Post - Category: Science Source Type: news
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - Category: Science Source Type: news
This patient's clinical presentation, with peripheral noninfectious, stromal keratitis, is highly suggestive of and most often associated with an underlying systemic immune-mediated disease, although other etiologies such as neoplasia can masquerade in a similar manner. The contiguous pattern involving several clock hours of the peripheral cornea while maintaining relatively good vision and little inflammation throughout the uninvolved stroma further supports a nonmicrobial cause. Uncommon exceptions to this include ocular tuberculosis, syphilis, leprosy, and Lyme disease, which can all mimic peripheral noninfectious keratitis.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Consultation section: Cornea Source Type: research
CONCLUSION: This study highlights the superiority of Group 1 compared to Group 2 when analyzing the results. Although Group 1 was statistically superior to Group 2, the Limitations by Emotional Aspects criteria showed no statistical difference in both. One might speculate as hypothesis for this finding, aspects that go beyond pharmacotherapy, such as the impact of stigma related to the presence of cutaneous manifestations.Disclosure: Dr. Dornas has nothing to disclose. Dr. Nascimento has nothing to disclose. Dr. Pupe has nothing to disclose. Dr. Araujo has nothing to disclose. Dr. Davidovich has nothing to disclose. Dr. Vi...
Source: Neurology - Category: Neurology Authors: Tags: Lyme and Other CNS Infections Source Type: research
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