Comparison Between INSPIRE and Domjan method for measuring lumbar lateral flexion in patients of psoriatic arthritis (PsA) and correlation with radiographic damage

ConclusionBoth INSPIRE and Domjan methods correlate well as measures of SLF in PsA and correlate with radiographic damage. Therefore, the simpler INSPIRE method may be used to measure SLF in PsA.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research

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AbstractPurpose of ReviewThe purpose of this review is to educate the reader about the evolving classification of axial spondyloarthritis (AxSpA) and describe recent treatment data from clinical trials of medications with mechanisms of action other than TNF inhibition. The review will also address emerging treatment strategies for AxSpA.Recent FindingsNew and more sensitive classification schema for AxSpA find that the prevalence of the disease is more than twice that of the historic definition of ankylosing spondylitis (AS), when patients without radiographically observable damage to the sacroiliac joints are included. TN...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
Purpose of review Treat-to-target (T2T) is an emerging management strategy in axial spondyloarthritis (axSpA). The concept was originally based on evidence from other chronic conditions, such as hypertension, diabetes and hypothyroidism, as well as some rheumatic diseases, such as rheumatoid arthritis and gout. The purpose of this review is to discuss the arguments against and in favour of adopting a T2T strategy in the management of axSpA. Recent findings International groups have recommended a T2T strategy in axSpA. Inactive disease according to the Ankylosing Spondylitis Disease Activity Score (ASDAS) has been sugg...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: SPONDYLOARTHROPATHIES: Edited by Atul A. Deodhar Source Type: research
Conditions:   Rheumatoid Arthritis;   Psoriatic Arthritis;   Ankylosing Spondylitis;   Non-Radiographical Axial Spondyloarthritis Interventions:   Drug: Filgotinib;   Drug: Placebo;   Drug: Standard of Care Sponsors:   Galapagos NV;   Gilead Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 6 March 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Jean W. Liew, Sofia Ramiro, Lianne S. GenslerAbstractThe cardiovascular burden in inflammatory rheumatic diseases is well recognized. Recently, this burden has been highlighted in ankylosing spondylitis (also known as radiographic axial spondyloarthritis) and psoriatic arthritis. We review the cardiovascular morbidity and mortality in these diseases, as well as the prevalence and incidence of traditional cardiovascular risk factors. We examine the contribution of anti-inflammatory therapy with nonsteroidal ant...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
DiscussionAnkylosing spondylitis (also known as Bechterew disease and Marie Str ümpell disease). More common in males with 3:1 ratio.Spondyloarthritis is a group of diseases with common clinical, laboratory, and genetic features&association with human leukocyte antigen HLA-B27. Ankylosing spondylitis is the prototypic disease in the spectrum of spondyloarthritis which usually has axial skeletal manifestations. Other representative disorders in this spectrum of disease which usually have peripheral articular involvement, but axial skeleton manifestations are also frequently seen are --psori...
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs
ConclusionsSpinal diffuse idiopathic skeletal hyperostosis is a common bone-forming disorder in the middle-aged and older population. Its recognition is important because this condition can render the spine susceptible to fractures even with minor trauma, such as ground-level fall, resulting in delayed diagnosis and neurologic deterioration.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Abstract The classification of axial spondyloarthritis (axSpA) comprises the classical ankylosing spondylitis (AS), which is characterized by already existing structural changes in the sacroiliac joints, and the so-called non-radiographic axSpA (nr-axSpA), in which by definition such changes are not present. This distinction is based on the ASAS classification criteria for axSpA, which are however not suitable for a diagnosis. According to the current classification, spondyloarthritis (SpA) includes axSpA, which can be associated with psoriasis and/or chronic inflammatory bowel diseases (CED), such as Crohn's dise...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
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