Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats.

In conclusion, social isolation at adulthood induced epigenetic alterations and exacerbated the effects of chronic stress on HDAC5. Notwithstanding, social support counteracted the adverse effects of stress on HDAC5 expression.
PMID: 30880220 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - March 13, 2019 Category: Neurology Authors: Borges JV, de Freitas BS, Antoniazzi V, de Souza Dos Santos C, Vedovelli K, Pires VN, Paludo L, de Lima MNM, Bromberg E Tags: Behav Brain Res Source Type: research