Phosphatase inhibitor PPP1R11 modulates resistance of human T cells toward Treg-mediated suppression of cytokine expression.

In conclusion, we present PPP1R11 as a novel negative regulator of T cell activation-induced cytokine expression. Targeting PPP1R11 may have therapeutic potential to regulate the T cell activation status including modulating the susceptibility of T cells toward Treg-mediated suppression, specifically altering the stimulation-induced T cell cytokine milieu. PMID: 30882958 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30882958?dopt=Abstract

Source: Journal of Leukocyte Biology - March 17, 2019 Category: Hematology Authors: Joshi RN, Fernandes SJ, Shang MM, Kiani NA, Gomez-Cabrero D, Tegnér J, Schmidt A Tags: J Leukoc Biol Source Type: research