Rutaecarpine prevented ox-LDL-induced VSMCs dysfunction through inhibiting overexpression of connexin 43.

In conclusion, this study demonstrated that rutaecarpine inhibited Cx43 overexpression through TRPV1/[Ca2+]i/CaM/NF-κB signal pathway, thereby preventing VSMCs dysfunction induced by ox-LDL. Our study provides a novel mechanism by which rutaecarpine modulate Cx43 expression and VSMC function. PMID: 30880182 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30880182?dopt=Abstract

Source: European Journal of Pharmacology - March 13, 2019 Category: Drugs & Pharmacology Authors: Wang M, Wu Y, Yu Y, Fu Y, Yan H, Wang X, Li T, Peng W, Luo D Tags: Eur J Pharmacol Source Type: research