Pseudomonas aeruginosa biofilm is a potent inducer of phagocyte hyperinflammation

ConclusionsPhagocytes exposed to biofilm microenvironment, called by us biofilm-associated neutrophils/macrophages (BANs/BAMs), display secretory properties similar to that of N1/M1-type phagocytes. These results suggest that in vivo high concentrations of LPS and DNA, trapped in biofilm by EPS, might convert infiltrating phagocytes into cells responsible for tissue injury without direct contact with bacteria and phagocytosis.

Source: Inflammation Research - March 17, 2019 Category: Research Source Type: research