Genesis, genes and epigenetics of endometriosis-associated infertility

Genesis, genes and epigenetics of endometriosis-associated infertilityGenesis, genes and epigenetics of endometriosis-associated infertility, Published online: 18 March 2019; doi:10.1038/s41574-019-0191-9Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated with aberrant hormonal signalling and increased fibrosis in the endometrium and impaired endometrial receptivity.

Source: Nature Reviews Endocrinology - March 17, 2019 Category: Endocrinology Authors: Sun-Wei Guo Source Type: research