Cancers, Vol. 11, Pages 381: Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies

Cancers, Vol. 11, Pages 381: Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies Cancers doi: 10.3390/cancers11030381 Authors: Annese Tamma Ruggieri Ribatti Angiogenesis is a crucial event in tumor development and progression, occurring by different mechanisms and it is driven by pro- and anti-angiogenic molecules. Pancreatic cancer vascularization is characterized by a high microvascular density, impaired microvessel integrity and poor perfused vessels with heterogeneous distribution. In this review article, after a brief introduction on pancreatic cancer classification and on angiogenesis mechanisms involved in its progression, the pre-clinical and clinical trials conducted in pancreatic cancer treatment using anti-angiogenic inhibitors will be described. Finally, we will discuss the anti-angiogenic therapy paradox between the advantage to abolish vessel supply to block tumor growth and the disadvantage due to reduction of drug delivery at the same time. The purpose is to identify new anti-angiogenic molecules that may enhance treatment regimen.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research