Mixed ligand ternary complexes of Co(II), Ni(II), Cu(II) and Zn(II) and their structural characterization, electrochemical, theoretical and biological studies

Publication date: Available online 17 March 2019Source: Journal of Molecular StructureAuthor(s): G. Sasikumar, S. Arulmozhi, A. Ashma, A. Sudha, S.J. Askar aliAbstractThis research work was emphasized about synthesis of mixed ligands of Co(II), Ni(II), Cu(II) and Zn(II) complexes of the type [M(L)(phen)] 1–4 and [M(L)(bpy)] 5–8 where, L = potassium (S, E)-2-((5-bromo-2-hydroxybenzylidene)amino)propanoate (derived from 5-bromosalicylaldehyde and l-alanine), phen = 1, 10 phenanthroline and bpy = 2, 2′-bipyridyl. Both phen and bpy act as an auxiliary ligand. The synthesized metal(II) complexes characterized by a spectral technique like CHN analysis, electronic spectroscopy, FT-IR, NMR, ESI-Mass spectrometry, EPR, Powdered X-ray diffractometry, and cyclic voltammetry. From spectral arguments, the geometry of complexes displayed five coordination through Schiff base ligand (ONO) and diimine (NN) donor and expected to give the distorted square pyramidal geometry around metal atoms. In vitro cytotoxicity of the Cu(II) complexes (3 and 7) were checked by MTT assay towards three cancer cell lines such as human lung cancer (A549), cervical cancer (HeLa), human breast cancer (MCF-7) and one normal cell line like nontumorigenic human dermal fibroblast cell line (NHDF). The cell viability of those complexes showed an only a moderate effect on cancerous cells when compared with the drug cisplatin. In the molecular docking studies, all the metal(II) complexes showed hydrog...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research