Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1 α/VEGF pathway

In conclusion, FBXO22 promoted the migration and invasion of tumor cells and melanoma angio genesis via HIF-1α upregulation. This study demonstrated that FBXO22 knockdown suppressed tumor progression and metastasis, suggesting that FBXO22 might be developed as a novel target for treating patients with MM.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research