Speech and language intervention for language impairment in patients in the FTD-ALS spectrum.

Speech and language intervention for language impairment in patients in the FTD-ALS spectrum. Hell J Nucl Med. 2019 Jan-Apr;22 Suppl:133-146 Authors: Kiousi V, Arnaoutoglou M, Printza A Abstract Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease that belongs to the group of motor neuron diseases. Motor deficits like reduce in tongue strength, may coexist with cognitive deficits compatible with frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD). FTD is a neurodegenerative syndrome with two main clinical variants: behavioral (bvFTD) and language or Primary Progressive Aphasia (PPA). ALS and FTD have significant clinical and neuropathological overlapping so that for some researchers they are "the ends of the same disease spectrum". A key intervention in this patient population is the speech language therapy (SLT), a specific form of cognitive intervention, which evaluates communication skills and designs a personalized intervention plan to improve communication abilities. It has been used in patients with aphasia of different etiologies and has been shown to be effective. There is limited research in SLT interventions in patients in FTD-ALS spectrum, and the initial findings indicate success to some extent. Due to progressive neurodegeneration in FTD-ALS spectrum, the main goal of the intervention is not the complete rehabilitation of linguistic deficits but the reduction and, if poss...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

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Authors: Zhang H, Cao Y, Pei H, Wang H, Ma L, Wang Z, Diao X, Yang Y, Liu N, Wei Y, Li H Abstract Shenmayizhi formula (SMYZF) has been shown to have an effect on vascular dementia (VaD) in previous studies. The aim of this study was to evaluate whether a combination of SMYZF with Ginkgo extract tablets improves mild-to-moderate VaD. In this 12-week, randomized, double-blind, controlled study, we randomly assigned 196 patients with VaD (aged 50-85 years) to either the SMYZF group (n = 98) or the Ginkgo group (n = 98). All patients received Ginkgo extract tablets as a basic treatment, whil...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Abstract OBJECTIVE: To ascertain the characteristics of the nursing care provided to institutionalized elderly people with dementia. METHODS: Integrative review of studies published between 2013 and 2017, in English, Spanish, and Portuguese, from the databases BDENF, LILACS, CINAHL, PubMed, SciELO, TRIP, and National Guideline Clearing House. Thematic data analysis was used. RESULTS: From the data collected in the 41 included studies, three themes emerged: Care with a focus on the needs of elderly people in LTCIEs; Care based on the work process of the nursing team; and Shared care. Final considerations:...
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
This article explores the relationship between falls and dementia, including the importance of rehabilitation strategies for reducing fall risk in these individuals. PMID: 32773046 [PubMed - in process]
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Med Clin North Am Source Type: research
Conclusions: This understanding can open up the need for a gut related approach in these disorders as well as unlock the door for the role of gut related microbiota management. Key Messages:Challenges of managing mental health conditions remain in spite of new pharmacological therapy.Gut dysbiosis is seen in various mental health conditions.Various psychotropic medications can have an influence on the gut microbiota by their antimicrobial effect. PMID: 32772900 [PubMed - as supplied by publisher]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
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Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 149Author(s): James B. RoweAbstractFrontotemporal dementia is a clinically and pathologically heterogeneous group of neurodegenerative disorders, with progressive impairment of behavior and language. They can be closely related to amyotrophic lateral sclerosis, clinically and through shared genetics and similar pathology. Approximately 40% of people with frontotemporal dementia report a family history of dementia, motor neuron disease or parkinsonism, and half of these familial cases are attributed to mutations in three genes (C9orf72, MAPT and PGRN...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 21 November 2019Source: International Review of NeurobiologyAuthor(s): James B. RoweAbstractFrontotemporal dementia is a clinically and pathologically heterogeneous group of neurodegenerative disorders, with progressive impairment of behavior and language. They can be closely related to amyotrophic lateral sclerosis, clinically and through shared genetics and similar pathology. Approximately 40% of people with frontotemporal dementia report a family history of dementia, motor neuron disease or parkinsonism, and half of these familial cases are attributed to mutations in three genes (C9orf...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Conclusions: The association between selective autoimmune disease and neurodegenerative disorders unified by the underlying pathology frontotemporal lobar degeneration with TDP-43–positive inclusions (FTLD-TDP) extends to C9 and FTD/MND cohorts, providing further evidence that select autoimmune inflammation may be intrinsically linked to FTLD-TDP pathophysiology.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Amyotrophic lateral sclerosis, Frontotemporal dementia, Case control studies Article Source Type: research
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Source: Journal of Neurochemistry - Category: Neurology Authors: Tags: Review Source Type: research
Conclusion: OCs most frequently occur prior to the clinical diagnosis of FTD (in 78.3[percnt] of cases, 0 to 27 years before) and also co-occur with other psychiatric conditions like anxiety, depression and psychosis. Late-onset OCs can precede frank FTD, and thus merit further attention as an early marker of FTD.Disclosure: Dr. Santibanez has nothing to disclose. Dr. Sepehry has nothing to disclose. Dr. Feldman has received personal compensation for activities with Merck, Eli Lilly and Arena and Eisai and Genentech Banne as a member of safety and diagnostic monitoring committees. Dr. Hsiung has received research support f...
Source: Neurology - Category: Neurology Authors: Tags: Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Source Type: research
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