A structural in silico analysis of the immunogenicity of l-asparaginase from Escherichia coli and Erwinia carotovora.

This study showed that there are no significant differences in the level of immunogenicity between both enzymes, while asparaginase from E. coli presented a higher relative frequency of allergenic epitopes. These results are consistent with previously published reports. However, from a structural point of view, in our knowledge, this is the first research describing the structural antigenic determinants that contribute to the hypersensibility response to this treatment. PMID: 30871932 [PubMed - as supplied by publisher]
Source: Biologicals : Journal of the International Association of Biological Standardization - Category: Biotechnology Authors: Tags: Biologicals Source Type: research