Cellular Gene Expression during Hepatitis C Virus Replication as Revealed by Ribosome Profiling.

CONCLUSION: After establishing HCV replication, the lack of global changes in cellular gene expression indicates an adaptation to chronic infection, while the downregulation of mitochondrial respiratory chain genes indicates how a virus may further contribute to cancer cell-like metabolic reprogramming ("Warburg effect") even in the hepatocellular carcinoma cells used here.
PMID: 30875926 [PubMed - in process]

Source: Molecular Medicine - March 14, 2019 Category: Molecular Biology Authors: Gerresheim GK, Bathke J, Michel AM, Andreev DE, Shalamova LA, Rossbach O, Hu P, Glebe D, Fricke M, Marz M, Goesmann A, Kiniry SJ, Baranov PV, Shatsky IN, Niepmann M Tags: Int J Mol Sci Source Type: research