A phenanthroindolizidine glycoside with HIF-1 inhibitory activity from Tylophora atrofolliculata

Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Cheng-Yu Chen, Guo-Yuan Zhu, Tang-Gui Xie, Ping-Chuan Jiang, Jing-Rong Wang, Zhi-Hong JiangAbstractA phenanthroindolizidine glycoside 6-O-β-D-glucopyranosyl-tylophorinidine (1), the first glycoside of phenanthroindolizidine alkaloid in nature, was isolated from whole plants of Tylophora atrofolliculata (Asclepiadaceae). Its structure was elucidated by means of spectral and chemical evidences. Compound 1 showed potent inhibitory effect (IC50: 69 ± 13 nM) on hypoxia induced factor-1 (HIF-1) activation. It was discovered that glucosylation at C-6 of 1 could lead to reduction in cytotoxicity against normal cells and enhance its selectivity in tumor cells inhibition.Graphical abstract

Source: Phytochemistry Letters - March 16, 2019 Category: Chemistry Source Type: research