Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data

Publication date: April 2019Source: The Lancet Global Health, Volume 7, Issue 4Author(s): Tanwei Yuan, Thomas Fitzpatrick, Nai-Ying Ko, Yong Cai, Yingqing Chen, Jin Zhao, Linghua Li, Junjie Xu, Jing Gu, Jinghua Li, Chun Hao, Zhengrong Yang, Weiping Cai, Chien-Yu Cheng, Zhenzhou Luo, Kechun Zhang, Guohui Wu, Xiaojun Meng, Andrew E Grulich, Yuantao HaoSummaryBackgroundMen who have sex with men (MSM) are disproportionately affected by HIV and other sexually transmitted infections (STIs) worldwide. Previous reviews investigating the role of circumcision in preventing HIV and other STIs among MSM were inconclusive. Many new studies have emerged in the past decade. To inform global prevention strategies for HIV and other STIs among MSM, we reviewed all available evidence on the associations between circumcision and HIV and other STIs among MSM.MethodsIn this systematic review and meta-analysis, we searched PubMed, Web of Science, BioMed Central, Scopus, ResearchGate, Cochrane Library, Embase, PsycINFO, Google Scholar, and websites of international HIV and STI conferences for studies published before March 8, 2018. Interventional or observational studies containing original quantitative data describing associations between circumcision and incident or prevalent infection of HIV and other STIs among MSM were included. Studies were excluded if MSM could not be distinguished from men who have sex with women only. We calculated pooled odds ratios (ORs) and their 95% CIs using random-eff...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research