Powerhouse of the mind: mitochondrial plasticity at the synapse.

Powerhouse of the mind: mitochondrial plasticity at the synapse.
Curr Opin Neurobiol. 2019 Mar 12;57:149-155
Authors: Rossi MJ, Pekkurnaz G
Abstract
Neurons are highly polarized cells with extraordinary energy demands, which are mainly fulfilled by mitochondria. In response to altered neuronal energy state, mitochondria adapt to enable energy homeostasis and nervous system function. This adaptation, also called mitochondrial plasticity, can be observed as alterations in the form, function and position. The primary site of energy consumption in neurons is localized at the synapse, where mitochondria are critical for both pre- and postsynaptic functions. In this review, we will discuss molecular mechanisms regulating mitochondrial plasticity at the synapse and how they contribute to information processing within neurons.
PMID: 30875521 [PubMed - as supplied by publisher]

Source: Current Opinion in Neurobiology - March 11, 2019 Category: Neurology Authors: Rossi MJ, Pekkurnaz G Tags: Curr Opin Neurobiol Source Type: research