Pegvisomant improves Glucose Metabolism in Acromegaly: a meta-analysis of prospective interventional studies.

CONCLUSIONS: Independently of disease control, PEG in monotherapy or combined with SSAs seems to improve glucose metabolism, reducing FPG, HbA1c, FPI and HOMA-I. PMID: 30869797 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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ConclusionTreatments used to normalize IGF-I levels in patients with acromegaly could have differential effects on cardiovascular risk factors and metabolic parameters.
Source: Endocrine - Category: Endocrinology Source Type: research
Authors: Yonenaga M, Fujio S, Habu M, Arimura H, Hiwatari T, Tanaka S, Kinoshita Y, Hosoyama H, Hirano H, Arita K Abstract The criteria for surgical cure of acromegaly have become more stringent during the past decades and a change from Cortina to new consensus criteria has recently been proposed. However, the superiority of the new consensus over Cortina criteria with respect to postoperative metabolic parameters remains to be ascertained. We retrospectively assessed metabolic parameters, the body habitus, and other health-related parameters of 48 patients with surgically controlled acromegaly who met the Cortina ...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Conclusion There is some reduction in cardiovascular risk factors with control of the disease, but possibly without the return to basal levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Conclusions FGF-21 levels were similar in patients with acromegaly compared to controls. However, our results indicate that FGF-21 may have a potential role in the development of acromegaly complications. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
ConclusionThe risk-allele frequencies of studied polymorphisms in acromegaly were higher than in general European population. There is an association betweenFTO gene polymorphisms and HDL cholesterol concentration, suggestingFTO gene polymorphisms may be associated with higher CVD risk in patients with acromegaly.
Source: Pituitary - Category: Endocrinology Source Type: research
ConclusionsGlucose and lipid levels were not detrimentally affected in most patients, while only a relatively small proportion showed deterioration in glucose control.
Source: Clinical Endocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research
This article discusses the clinical features, pathophysiology, and management of toxic and endocrine myopathies. Recent Findings: Early detection and expeditious correction of metabolic disturbances in endocrinopathies such as Cushing syndrome, thyroid and parathyroid diseases, and acromegaly can minimize and prevent neurologic complications including myopathy. Recently proposed mechanisms of injury in patients with critical illness myopathy include inhibition of protein synthesis, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, oxidative stress, and disruption of intramuscular calcium homeostasi...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: Review Articles Source Type: research
ConclusionsGlucose and lipid levels were not detrimentally affected in most patients, while only a relatively small proportion showed deterioration in glucose control.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Conclusions Elevated serum PON levels were detected in acromegalic patients, independently of their remission status. This suggests protective effects for cardiometabolic risk parameters. PMID: 26863932 [PubMed - as supplied by publisher]
Source: Redox Report : communications in free radical research - Category: Biochemistry Authors: Tags: Redox Rep Source Type: research
Abstract Free 25-hydroxyvitamin D [25(OH)D] is suggested to be important in the determination of vitamin D deficiency, since vitamin D-binding protein (VDBP) may affect total 25(OH)D levels. There are no data about free 25(OH)D concentrations in acromegaly. We aimed to investigate serum VDBP and total and free 25(OH)D levels in patients with acromegaly in comparison with control subjects. We recruited 54 patients with acromegaly and 32 control subjects who were similar according to age, gender, and body mass index. Serum VDBP levels were found to be increased in patients with acromegaly compared to control subject...
Source: Endocrine - Category: Endocrinology Source Type: research
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