Stress test of liver function using technetium-99m-mebrofenin hepatobiliary scintigraphy

Technetium-99m (99mTc) mebrofenin hepatobiliary scintigraphy (HBS) enables a quantitative assessment of liver function. This is normally performed in a fasting state and might therefore reflect the resting liver function. We evaluated the change in liver function using HBS after stimulation with an oral metabolic challenge. Healthy volunteers aged 50–60 (n=12) or older than or equal to 75 (n=12) years underwent two sequential HBS. The first scan was performed after an overnight fast and the second scan was performed after the administration of chocolate milk. Hepatic 99mTc-mebrofenin uptake rate (cMUR) was calculated and the difference was expressed as percentage. cMUR after fasting was 10.9±2.5%/min/m2 (mean±SD) and increased by 20% to 13.0±3.1%/min/m2 after stimulation with chocolate milk (P
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: TECHNICAL NOTE Source Type: research