Engineered Mesenchymal Stromal Cell Therapy during Pig Ex Vivo Lung Perfusion and Transplant

Ex vivo lung perfusion (EVLP) enables novel therapeutic approaches to repair damaged lungs for transplantation. We investigated the concept and feasibility of elective cell therapy for donor lungs. Dosing, efficacy and transgene expression kinetics of engineered mesenchymal stromal cell therapy were examined in pig EVLP and transplantation.

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A.I. Nykanen, A. Mariscal, M. Takahashi, A. Duong, A. Ali, M. Chen, A. Takahagi, H. Gokhale, C. Estrada, T. Martinu, S. Juvet, J. Yeung, T.K. Waddell, M. Cypel, M. Liu, J.E. Davies, S. Keshavjee Tags: 8 Source Type: research