Tolerance Induction by Myeloid Progenitor Cells Does Not Require Lethal Preconditioning or Hematopoietic Stem Cell Transplantation

Modulation of the immune system using cellular therapy is seen as an increasingly attractive option to prevent solid organ graft rejection, while maintaining sufficient immune function to prevent many of the complications associated with general immunosuppression. We have previously demonstrated that murine myeloid progenitor cells (mMPC), cryopreserved after expansion in vitro, induce robust tolerance for matched organ grafts when preconditioning included lethal whole body irradiation and third party hematopoietic stem cell transplantation (HSC).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 73 Source Type: research