Experimental Venous Congestion Causes Peripheral Release of Angiopoietin-2 and Tissue Necrosis Factor- α - A New Insight into the Pathophysiology of Gastrointestinal Bleeding in CF-LVAD Patients

Gastrointestinal bleeding (GIB) from angiodysplasia is the most frequent cause of readmission in LVAD patients. Angiogenesis, inflammation and coagulopathy as well as venous congestion (VC) are hypothesized to contribute to GIB pathophysiology. We used an established experimental model of peripheral VC to investigate whether increased venous pressure alters plasma levels of angiopoietin-2 (Ang-2) tumor necrosis factor- α (TNF-α) and vonWillebrand factor (vWF).

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P.C. Colombo, F. Castagna, D. Onat, S.M. Lagana, W.Y. Ka, E.A. Royzman, A.S. Faye, J.E. Axelrad, T.A. Gonda, A.R. Garan, H. Takayama, K. Takeda, Y. Naka, G. Parkis, M. Yuzefpolskaya, R. Demmer Tags: 312 Source Type: research