HLA-G 14BP Polymorphism Matching Protects against Development of Post-Transplant Malignancy Following Heart Transplantation

Post-transplant malignancy (PTM) is a major cause of morbidity and mortality following transplantation. Human leukocyte antigen G (HLA-G) is an immune checkpoint molecule that reduces allograft rejection by dampening the host immune response. Reports suggest HLA-G may be utilized by malignant cells to evade the immune system and promote cancer development. Our objective was to evaluate HLA-G donor/recipient genotype matching and development of PTM following heart transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 330 Source Type: research