Reconstruction of Transcriptional Programs of Monocyte to Macrophage Sequential Cell Fate Transition Using Single Cell RNA Sequencing in Sex Mis-Matched Lung Transplantation

Alveolar macrophages are key regulators of the innate immune response and participate in the stem cell niche to organise tissue repair and lung homeostasis. The fate of donor alveolar macrophages is poorly understood as existing studies have relied on sex chromosome labelling or HLA typing methodologies. We sought to confirm the existence of a long-lived pool of donor-derived alveolar macrophages using single cell RNA sequencing in sex mismatched lung transplant patients.

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: B. O'Sullivan, J. Powell, S. Lukowski, M. Tan, P. Hopkins, D. Chambers Tags: 365 Source Type: research