Clinical Parameters of Right Ventricular Dysfunction Predict Depressed RV Myofilament Function

Right ventricular dysfunction (RVD) in heart failure with reduced ejection fraction (HFrEF) drives morbidity and mortality. Clinical hemodynamic parameters such as elevated right atrial pressure to pulmonary capillary wedge pressure ratio (RAP/PCWP) and low pulmonary artery pulsatility index (PAPi) are widely used to identify patients with significant RVD. However, their correspondence to intrinsic RVD is unknown. We therefore tested whether RAP/PCWP or PAPi are associated with sarcomere and molecular dysfunction.

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M.I. Aslam, B. Lin, D. Kass, S. Hsu Tags: 594 Source Type: research