Modeling Right Ventricular Heart Failure in Congenital Heart Disease

Heart failure is a significant cause of morbidity and mortality in congenital heart disease patients especially for the subset whose right ventricle functions as the systemic ventricle. The physiological and molecular differences in the right ventricle (RV) and left ventricle (LV) lead to different abilities to adapt to adverse conditions and respond to pharmacological therapeutics. Currently data describing the molecular changes that occur in the systemic RV are lacking. Available animal models create an RV with volume and/or pressure overload however the LV remains at high pressure.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 600 Source Type: research