Orthotopic Implantation with Immature Mouse Fetal Lung Did Not Self-Organize Airways Structures, but Improved Prognosis of Mice with Paraquat-Induced Severe Lung Injury

Lung transplantation is an effective therapy for end-stage patients with chronic respiratory failure due to various benign lung diseases. The organ shortage crisis is a serious problem, so it is required to develop alternative therapies. There have been reports of organ organoids ameliorating organ function but there have been few reports of lung organoids being capable of restoring respiratory function. We therefore hypothesized that immature mouse fetal lungs would ameliorate severe respiratory failure and connect the airways between recipient and donor lungs.

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: R. Okabe, T. Chen-Yoshikawa, A. Yoshizawa, T. Hirashima, F. Gochi, H. Yamagishi, A. Takahagi, M. Saito, A. Ohsumi, D. Nakajima, M. Hamaji, H. Date, T. Takebe Tags: 629 Source Type: research