Positive Familial History Poses a Higher Risk for No Spontaneous Recovery in Patients with Peripartum Heart Failure: Left Ventricular Assist Device Implantation and Transplantation with Bromocriptine as Novel Therapeutic Options in These Patients

Peripartum cardiomyopathy (PPCM) is a rare, but serious and potentially life-threatening condition. The nursing hormone Prolactin has been hypothesized as potential pathogenic factor of PPCM. Positive family history could be a reason for genetically caused peripartum heart failure that has possibly been demasked by the physiological pregnancy stress in a subset of patients. From animal models mutations in STAT3 may be involved in these genetic forms of PPCM.

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: K. Jawad, J. Erdmann, M. Borger, S. Eifert Tags: 969 Source Type: research