Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors

Secondary hemolytic uremic syndrome (HUS) is a heterogeneous group of thrombotic microangiopathies associated with various underlying conditions. Whether it belongs to the spectrum of complement-mediated HUS remains controversial. We analysed the presentation, outcome, and frequency of complement gene rare variants in a cohort of 110 patients with secondary HUS attributed to drugs (29%), autoimmune diseases (24%), infections (17%), malignancies (10%), glomerulopathies (9%), extra-renal organ transplantation (8%), and pancreatitis (3%).

Source: Kidney International - March 14, 2019 Category: Urology & Nephrology Authors: Alice Le Clech, No émie Simon-Tillaux, François Provôt, Yahsou Delmas, Paula Vieira-Martins, Sophie Limou, Jean-Michel Halimi, Moglie Le Quintrec, Ludivine Lebourg, Steven Grangé, Alexandre Karras, David Ribes, Noémie Jourde-Chiche, Eric Rondeau, Vé Tags: Clinical Investigation Source Type: research