Non-HLA Agonistic Anti-Angiotensin II Type 1 Receptor Antibodies Induce a Distinctive Phenotype of Antibody-mediated Rejection in Kidney Transplant Recipients

Anti-angiotensin II type 1 receptor (AT1R) antibodies have been associated with allograft rejection. We hypothesized that circulating AT1R antibodies might identify kidney transplant recipients at increased risk of allograft rejection and loss who are not identified by the HLA system. We prospectively enrolled 1845 kidney transplant recipients from two centers. Donor-specific HLA antibodies (DSAs) and AT1R antibodies were measured at the time of the first acute rejection episode or at 1 year post-transplant.

Source: Kidney International - March 14, 2019 Category: Urology & Nephrology Authors: Carmen Lefaucheur, Denis Viglietti, Yassine Bouatou, Aur élie Philippe, Daniele Pievani, Olivier Aubert, Jean-Paul Duong Van Huyen, Jean-Luc Taupin, Denis Glotz, Christophe Legendre, Alexandre Loupy, Philip F Halloran, Duska Dragun Tags: Clinical Investigation Source Type: research