GSE107933 Transcriptome analysis of TNFR1-knockout mouse colon

CONCLUSIONS: TNFR1 promotes epithelial homeostasis and regulates commensal exposure. T he lack of TNFR1 accelerates the onset and severity of IBD in the absence of tolerogenic signaling (i.e., lack of IL-10). Il10-/- Tnfr1-/- mice may serve as a valuable model of very-early-onset IBD (VEO-IBD).
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research