Is multifocal regression a risk factor for ipsilateral breast tumor recurrence in the modern era after neoadjuvant chemotherapy and breast conservation therapy?

We aimed to determine the significance of multifocal regression after neoadjuvant chemotherapy as a predictor of ipsilateral breast tumor recurrence (IBTR) in the modern era. In this retrospective review of 346 patients, multifocal regression, hormone receptor-negative phenotype, and lack of nodal pathologic complete response predicted for increased risk of IBTR on multivariate analysis. Although more common in hormone receptor-positive disease, multifocal regression was associated with worse outcome only in hormone receptor-negative patients.

Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2019 Category: Radiology Authors: Diane C. Ling, Philip A. Sutera, Nick A. Iarrobino, Emilia J. Diego, Atilla Soran, Ronald R. Johnson, Rohit Bhargava, Colin E. Champ, Sushil Beriwal Tags: Clinical Investigation Source Type: research