Cardiac risk grows with higher coronary calcium scores

Individuals with high CT coronary artery calcium scores -- at least 1,000 Agatston...Read more on AuntMinnie.comRelated Reading: ACC: Physicians omit CT CAC scores in 50% of cancer cases Could self-rated health improve CT CAC scoring? Heart societies endorse CT CAC for risk assessment High CT CAC scores in athletes do not increase mortality CCTA reveals statins may lower mortality in low-risk CAD
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Results could cause patients undue worry or inappropriate reassurance – and increase workload for GP teams Related items fromOnMedica Doctors campaign against ‘too much medicine’ NHS must improve access to screening to save lives Metastatic breast cancer goes undiagnosed for too long Statins of small and uncertain benefit in primary prevention Pharmacists could offer high-dose statins direct to patients
Source: OnMedica Latest News - Category: UK Health Source Type: news
We found that statin use might be associated with reduced risk of both low ‐ and high‐grade prostate cancer, but the reduced risk was observed only when statins had been used for a relatively longer duration or higher dose. Also, the statin‐related risk reduction was higher for prostate cancer of a higher Gleason score, and lipophilic statins might be more protective than hydrophilic statins against prostate cancer. AbstractBackgroundConflicting evidence suggests that statins act chemopreventively against prostate cancer (PCa). Whether the association of statin use with PCa risk is Gleason score ‐dependent, time‐...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Novel pharmacological therapies are in development for cancer, ranging from conventional chemotherapeutic drugs to molecular targeted drugs, antibody-based drugs, and immune checkpoint inhibitors, which are developed using new technologies. However, the increasing cost of new drug development is increasing the costs of national healthcare and putting pressure on government finances worldwide. Under these circumstances, drug repositioning (i.e. discovering novel effects of existing drugs, thereby allowing their use to treat other diseases) has become a major focus because of reliability and cost reduction. It is becoming in...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Review Article: Lifestyle Source Type: research
In this study, the most common reason that patients or their doctors stopped statins was the development of advanced cancer or other major illness. In my practice, I have also cared for many patients who have stopped taking statins or who express reluctance to take statins due to side effects. The most common side effect is muscle ache (typically tenderness or soreness of the large muscle groups, such as the biceps and thighs), which affects about 20% of statin takers and reverses when the statin is discontinued. There is also a slightly increased risk of diabetes with long-term statin use and, very rarely, liver problems....
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Healthy Aging Heart Health Source Type: blogs
(CNN) — Leading nutritional experts in the United States and the UK are fired up about new dietary recommendations claiming there’s no need to reduce your red and processed meat intake for good health. “This is a very irresponsible public health recommendation,” said Dr. Frank Hu, who chairs the nutrition department at the Harvard T.H. Chan School of Public Health. The new guidelines and five corresponding studies are part of a systematic analysis of existing research done by NutriRECS, a recently formed international group of nutritionists and health researchers. NutriRECS says its mission is to &l...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Syndicated Local CNN Red Meat Source Type: news
ConclusionsOur findings show that oncologists and physicians have a rational approach to deprescription in patients suffering from cancer with short-term (pancreatic and lung cancer) respectively long-term (breast and prostate cancer) survival rates. However, several patients were continuing potential inappropriate medications in the terminal stage of cancer.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 29 September 2019Source: Pharmacological ResearchAuthor(s): Sanaz Keshavarz Shahbaz, Mahvash Sadeghi, Khadije koushki, Peter E. Penson, Amirhossein SahebkarAbstractStatins beside their main effect on reducing the progression of cardiovascular disease through pharmacological inhibition of the endogenous cholesterol synthesis, have additional pleiotropic effects including antiinflammatory effects mediated through the induction of suppressor regulatory T cells (Tregs). Statin-induced expansion of Tregs reduces chronic inflammation and may have beneficial effects in autoimmune diseases. Howev...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsThese analyses suggest the pharmacokinetic profile of darolutamide is not affected by a number of commonly administered drugs in patients with nmCRPC. Although pharmacokinetic data have indicated that darolutamide has the potential to interact with rosuvastatin, used to assess DDI in these studies, this finding did not seem to translate into increased AEs due to statin use in the ARAMIS trial.Clinicaltrials.gov identifier: NCT02200614.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
Abstract Statins are long known class of medicines and the most frequently prescribed drugs in cardiovascular pharmacotherapy, widely ordered not only in patients suffering from dyslipidemia, but also in patients with coronary artery disease, acute coronary syndromes, diabetes mellitus, stroke, hypertension, and chronic kidney disease, with or without coexisting dyslipidemia. However, several clinical trials have shown, that the advantages of statins goes beyond their reduction of the cholesterol level. Some crucial isoprenoid mediators which are highly essential for the activation of different intracellular/signa...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Although colorectal cancer (CRC) screening has reduced the incidence and mortality from CRC, chemoprevention strategies have potential to further reduce CRC incidence and mortality. Chemoprevention agents might be used for average-risk as well as high-risk groups, and to prevent colorectal cancer recurrence after therapy. CRC chemoprevention agents that have been studied include aspirin, non-aspirin non-steroidal anti-inflammatory drugs, statins, agents that target metabolic pathways, and vitamins and minerals.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
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