Cystic fibrosis community claps back at Five Feet Apart romance flick
Five Feet Apart, debuting Friday, is a fictional film about two teens with cystic fibrosis that fall in love, but can't touch without endangering one another. The film and its ads have drawn criticism.
Conclusion: An electronic alert incorporated into the ED workflow to populate a discharge order set is effective to initiate asthma controller medication for poorly controlled pediatric patients. Additional data describing reasons for not prescribing ICS can further refine recommendations for ICS prescriptions, and provide a comprehensive strategy to support clinical decision for pediatric asthma control in acute care settings. PMID: 31226000 [PubMed - as supplied by publisher]
FDA expanded the indication for Symdeko for treatment of pediatric patients ages 6 years and older with cystic fibrosis who have certain genetic mutations.
Discussion –- Bronchial atresia usually is benign and asymptomatic and is incidental finding&clinical manifestations may range from recurrent pulmonary infections to mild wheezing and dyspnea. Bronchial atresia is a congenital abnormality resulting from focal interruption of a lobar, segmental, or subsegmental bronchus with associated peripheral mucus impaction (bronchocele, mucocele) and associated hyperinflation of the obstructed lung segment. The apicoposterior segmental bronchus of the left upper lobe is most common site to be involved, followed by segmental bronc...
The FDA has approved tezacaftor/ivacaftor tablets for use in children as young as 6 years with cystic fibrosis with certain genetic mutations in the CFTR gene.FDA Approvals
FRIDAY, June 21, 2019 -- The indication for a cystic fibrosis treatment, Symdeko (tezacaftor/ivacaftor) tablets, has been expanded to treat children ages 6 years and older with cystic fibrosis and certain genetic mutations, the U.S. Food and Drug...
Publication date: 5 November 2019Source: Journal of Molecular Structure, Volume 1195Author(s): Tooba Siddiqui, Mohammad Khalid Zia, Syed Saqib Ali, Haseeb Ahsan, Fahim Halim KhanAbstractHydrogen peroxide (H2O2) is an important signalling molecule and a non-radical reactive oxygen species (ROS) which can convert into more potent oxygen radicals leading to oxidative stress. The correlation between oxidative stress and the cellular proteinase-antiproteinase balance has been a major component in the development of several pathologies such as emphysema and cystic fibrosis. The present studies attempt to explore the functional i...
CF clinicians have long recognized the negative effect of malnutrition on outcomes in people with CF  and the importance of a high-calorie diet to support weight gain and growth  . Nutritional status has been widely accepted as one of the critical metrics for health in people with CF. Low BMI has been identified as one factor associated with larger mean annual lung function decline . Enteral feedings to increase caloric intake are used to support optimal weight gain in those at nutritional risk.
In recent years there has been a significant increase in the number of randomised controlled trials (RCTs) in CF. All eyes are focused on the therapeutic effect under investigation and what that could mean for people with CF. RCTs frequently contain a placebo (control) arm to function as a methodological safeguard for systematic bias, normal fluctuations in outcome measures, regression of outcome measures to the mean, and most importantly, the effect size of the therapeutic intervention . It is recognised that participants in the placebo arm of RCTs can experience improvement in patient-reported outcomes (e.g.
To conduct a systematic review of the evidence to determine the impact of cystic fibrosis (CF) on unaffected siblings.