Risk of Gynecomastia with Users of Proton Pump Inhibitors

ConclusionThis large retrospective cohort study suggests that patients who used PPIs are at higher risk of developing gynecomastia. Clinicians may want to convey this information to male patients who require long ‐term PPI therapy.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Brief Report Source Type: research

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CONCLUSION: Costoclavicular brachial plexus block is a good alternative for upper limb anesthesia distal to the elbow, being a safe and effective option for patients who are obese or have other limitations to the use of other upper limb blocking techniques. PMID: 31519300 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
by Craig Klugman, Ph.D.  “Mental illness and hatred pulls the trigger, not the gun” – President Trump, 4 August 2019 In 2019 (as of September 13), there have been 297 “mass shootings” (4 or more people killed or injured) in the United States resulting in 326 deaths and 1,229 injuries. The reason, according to Trump’s administration is untreated mental illness. According to many mental health specialists, lots of people with mental illness never injure another person and many of the shooters have not been diagnosed with a mental illness.…
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Featured Posts Psychiatric Ethics Public Health Social Justice gun control guns HARPA Source Type: blogs
CONCLUSIONS: Epidemiological figures emerging from this study confirm that trends in Lebanon are in line with a global pattern of decreasing age at menarche. Urban-rural differences suggest that higher caloric content of diet and consequent early overweight, more evident in urban areas, are likely determinants of younger menarche. Evidence from this study calls for an urgent implementation of comprehensive multisectoral obesity prevention in children in Lebanon. PMID: 31519350 [PubMed - as supplied by publisher]
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Publication date: Available online 14 September 2019Source: Molecular Genetics and MetabolismAuthor(s): Farrah Rajabi, Frances Rohr, Ann Wessel, Leslie Martell, Steven F. Dobrowolski, Per Guldberg, Flemming Güttler, Harvey L. LevyAbstractPhenylketonuria (PKU) is an autosomal recessive inborn error of metabolism caused by pathogenic variants in the phenylalanine hydroxylase gene (PAH). The correlation between genotype and phenotype can be complex and sometimes variable but often very useful for categorizing and predicting dietary tolerance and potential outcome. We reviewed medical records for 367 patients diagnosed wi...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
ConclusionsEndovascular coil fiducial placement for lung SBRT is associated with high procedural success rates and lower rates of clinically relevant complications than transthoracic marker placement.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsTransrenal anterograde ureteral occlusion using EVOH between vascular plugs could be considered a relatively safe and potentially valuable treatment option for refractory ureteral fistulae.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsThe clinical model with radiomic features demonstrated improved survival predictive performance than the model without radiomic features, thus suggesting incremental prognostic value of peritumoral radiomics as MR imaging biomarker in pretreatment glioblastoma.
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsHistogram parameters derived from Kep might be used as surrogate imaging biomarkers for microvessel density parameters in HNSCC. MinimumKep showed the highest correlation with vessel area and Mode Kep with vessel count.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Authors: Gustat J, Anderson CE, O'Malley K, Hu T, Tabak RG, Goins KV, Valko C, Litt JS, Eyler AA Abstract BACKGROUND: To assess how perceptions of the community built environment influence support for community policies that promote physical activity (PA). METHODS: A national cross-sectional survey assessed perceptions of the local built environment and support of community policies, including school and workplace policies, promoting PA. A random digit-dialed telephone survey was conducted in US counties selected on Behavioral Risk Factor Surveillance System data for high or low prevalence of obesity and inacti...
Source: Journal of Physical Activity and Health - Category: Sports Medicine Tags: J Phys Act Health Source Type: research
Authors: Bangi E Abstract In recent years, there has been growing interest in using Drosophila for drug discovery as it provides a unique opportunity to screen small molecules against complex disease phenotypes in a whole animal setting. Furthermore, gene-compound interaction experiments that combine compound feeding with complex genetic manipulations enable exploration of compound mechanisms of response and resistance to an extent that is difficult to achieve in other experimental models. Here, I discuss how compound screening and testing approaches reported in Drosophila fit into the current cancer drug discovery...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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