Inflammatory domains modulate autism spectrum disorder susceptibility during maternal nutritional programming

Publication date: Available online 15 March 2019Source: Neurochemistry InternationalAuthor(s): Roger Maldonado-Ruiz, Lourdes Garza-Ocañas, Alberto CamachoAutism spectrum disorder (ASD) is a complex neurodevelopmental disease which involves functional and structural defects in selective central nervous system (CNS) regions harming capability to process and respond to external stimuli. In addition to genetic background, etiological causes of ASD have not been fully clarified. Maternal immune activation (MIA) during pregnancy have been proposed as a potential etiological cause leading to aberrant synaptic pruning and microglia-mediated neurogenesis impairment. Several clinical studies suggest that pro-inflammatory profile during maternal obesity associates with a higher risk of having a child with autism. In this context, the effect of maternal programing by high fat diet overconsumption during pregnancy sets a pro-inflammatory profile partly dependent on an epigenetic program of immunity which promotes brain micro and macrostructural abnormalities in the offspring that might last through adulthood accompanied by phenotypic changes in ASD subjects. Of note, maternal programming of inflammation during development seems to integrate the CNS and peripheral immune system cross-talk which arrays central inflammatory domains coordinating ASD behavior. In this review, we discuss basic and clinical studies regarding the effects of obesity-induced MIA on peripheral immune cells an...
Source: Neurochemistry International - Category: Neuroscience Source Type: research

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We examined small study effects and excess significance. We did analyses under credibility ceilings. This review is registered with PROSPERO, number CRD42018091704.Findings46 eligible articles yielded data on 67 environmental risk factors (544 212 cases, 81 708 787 individuals) and 52 biomarkers (15 614 cases, 15 433 controls). Evidence of association was convincing for maternal age of 35 years or over (relative risk [RR] 1·31, 95% CI 1·18–1·45), maternal chronic hypertension (odds ratio [OR] 1·48, 1·29–1·70), maternal gestational hypertension (OR 1·37,...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
ASD half as likely in high-risk children if mothers took prenatal vitamins during first month Related items fromOnMedica MHRA tightens licence restrictions on valproate for women Caffeine in pregnancy linked to risk of child overweight Valproate in pregnancy linked to raised autism risk Hunt announces Medicines and Medical Devices Safety Review Most CCGs missing smoking target for pregnant women
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractStudies have examined the association between parental body mass index (BMI) and autism spectrum disorder (ASD) in offspring, with inconsistent results, especially regarding maternal obesity, overweight and underweight. Cochrane Library, EMBASE, PubMed and PsycINFO databases were searched up to March 2018 for relevant observational studies with no language restriction. Our literature search identified 13 eligible studies for meta-analysis (involving 943,293 children and 30,337 cases). For maternal BMI (13 studies), both maternal obesity [OR 1.41 (95% CI 1.19 –1.67)] and maternal overweight [OR 1.16 (95% CI 1....
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Obese, pregnant women with diabetes are more likely to have children with psychiatric disorders, such as ADHD or autism, according to a study published inPediatrics.Reuters
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
(Reuters Health) - Pregnant women who have both severe obesity and diabetes may be more likely to have children with autism, ADHD and other psychiatric disorders than mothers who don't have either condition during pregnancy, a new study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
(Natural News) Being obese before getting pregnant has been found to increase the chance of having a child with autism, according to a study. The study, conducted by researchers at Northwestern University, found that mothers whose waists were at least 80 centimeters (cm) before pregnancy had a 65 percent higher chance of giving birth to a child...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
PREGNANT women who are overweight before they conceive run a 65 per cent greater risk of having a baby with autism, research suggests.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
TUESDAY, March 20, 2018 -- The pre-pregnancy width of a woman's waist -- but not whether or not she is actually obese -- may be tied to autism risk in her children, new research suggests. What's behind the association remains unclear, the...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Purpose of review The current review addresses the importance of the prospective cohort design in large, unselected populations starting early in life for understanding the origins of childhood health disorders. Recent findings Cohort studies originating in healthy populations have contributed to great advances in health, especially in cardiovascular diseases, but have only recently been applied systematically to study the origins of childhood disorders. Several large population-based pregnancy and/or birth cohorts have been developed in different parts of the world, and these are beginning to contribute to better und...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: THERAPEUTICS AND TOXICOLOGY: Edited by Robert O. Wright Source Type: research
Location:College of Medicine, Veterinary and Life Sciences, Glasgow, United KingdomSalary:A stipend of£14,553& tuition feesClosing Date:10 January 2018 Supervisors: Dr Michelle Bellingham, Dr Amanda Drake, Prof Paul A. FowlerProject details: The fetal environment plays a key role in programming normal brain development in the womb. Maternal lifestyle factors such as malnutrition, obesity, smoking and alcohol consumption are associated with altered brain development and behaviour, including attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and anxiety disorders in the o...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
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