Osteoarthritis: Leptin levels linked to obesity-related knee OA

Nature Reviews Rheumatology 10, 698 (2014). doi:10.1038/nrrheum.2014.184 Levels of the proinflammatory adipokine leptin contribute nearly half of the total effect of obesity on knee osteoarthritis (OA), according to a study using two different methods of mediation analysis. These findings add to the accumulating evidence of a pathogenetic role for metabolic factors (including
Source: Nature Reviews Rheumatology - Category: Rheumatology Tags: Research Highlight Source Type: research