Pupillometric assessment of dysautonomia in pediatric bowel and bladder dysfunction: A pilot study

Bowel and Bladder Dysfunction (BBD) refers to a heterogeneous group of voiding disorders, accounting for an estimated 40 percent of pediatric urology visits. Symptoms of BBD include enuresis, urgency, and urinary retention, often accompanied by constipation. This pilot study aims to explore whether a pupillary response can be characterized for BBD, by examining the pupillary light reflex (PLR) before and after voiding among BBD patients. A total of 28 patients ages 7 to 21 were recruited from the Wetting, Infections, and Stooling Help (WISH) clinic at Children ’s National Medical Center.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research

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ConclusionsRVF is a distinct entity, which needs careful clinical examination. With proper planning for diagnosis and treatment, it can be managed at specialized centers. Care may be needed for the associated anomalies. The follow-up is an integral part of its management.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
ConclusionThis study highlights the role of conservative management with good outcomes in children with TZ bowel pull-through having hypertrophic nerve fibers and normal ganglion pattern. Children who underwent Duhamel ’s procedure had little impact with the presence of TZ at anastomotic margin and majority of those undergoing TERP benefitted from Botox injection. Conservative management can be attempted successfully to prevent redo surgical interventions as they can lead to poorer outcomes. Only those children not responding to conservative measures need to be planned for revision surgery.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
This study aims to investigate the efficacy and safety of acupuncture therapy for IBS patients compared with those of conventional treatments. We also aim to identify the optimal acupoint combination recommended for IBS and to clarify the clinical advantage of the “multiacupoint co-effect and synergistic effect.”Methods and analysisA total of 204 eligible patients who meet the Rome IV criteria for IBS will be randomly stratified into acupuncture group A, acupuncture group B, or the control group in a 1:1:1 ratio with a central web-based randomization system. The prespecified acupoints used in the control group ...
Source: Trials - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewNail aesthetic procedures, particularly the fashion of nail sculpting, gel nails and long-lasting polishes, have been expanding over the last years, with an increasing number of cases of allergic contact dermatitis both in aestheticians and customers. Clinical suspicion and interpretation of nail cosmetics patch test results require a general knowledge of the main current manicure techniques and chemicals used.Recent FindingsAllergic contact dermatitis (ACD) to nail cosmetics, previously attributed mostly to tosylamide formaldehyde resin (TSFR), is now mainly caused by (meth)acrylates. In addition ...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
In this issue of JAMA, Xie and colleagues report findings from an evaluation of adverse outcomes following initial prescriptions for tramadol or codeine among residents of Catalonia, Spain. Using 10 years of linked primary care and pharmacy claims data, the investigators used propensity score matching to assemble a cohort of 368  960 individuals who received an initial prescription for either tramadol or codeine. Initial receipt of a tramadol prescription, compared with codeine, was associated with a significantly higher 1-year cumulative incidence of all-cause mortality (absolute rate difference [ARD], 7.37 [95% CI, 6.0...
Source: JAMA - Category: General Medicine Source Type: research
This study assesses new evidence on the efficacy of VPR for the treatment of ODS, specifically focusing on inclusion criteria for surgery and the long-term outcomes. A search was performed of MEDLINE, EMBASE, Ovid and Cochrane databases on all studies reporting on VPR for ODS from 2000 to March 2020. No language restrictions were made. All studies on VPR were reviewed systematically. The main outcomes were intra-operative complications, conversion, procedure duration, short-term mortality and morbidity, length of stay, faecal incontinence and constipation, quality of life (QoL) score and patient satisfaction. Quality asses...
Source: Updates in Surgery - Category: Surgery Source Type: research
This propensity score –matched cohort study uses primary care data to assess the associations of tramadol, compared with codeine, with all-cause mortality and other adverse clinical outcomes (cardiovascular events, fractures, constipation, delirium, falls, opioid abuse/dependence, and sleep disorders) 1 year after firs t dispensation in outpatient settings in Catalonia, Spain.
Source: JAMA - Category: General Medicine Source Type: research
The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several aging-related diseases, such as Alzheimer’s disease, kidney injury, cancer, chronic obstructive pulmonary disease (COPD), vascular disease, muscular dystrophy and diabetes. Conversely, many exogenous and endogenous factors, several drugs, lifestyle changes and genetic manipulations were reported to exert therapeutic effects through increasing Klotho expression. In recent years, Klotho has been identified as a potential autophagy regulator. How Klotho may contribute...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Condition:   Constipation Intervention:   Device: TransiCap Sponsors:   Nottingham University Hospitals NHS Trust;   University of Nottingham Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Secondary exposure to toxic asbestos has declined dramatically in recent decades, but known cases of malignant mesothelioma caused by that type of asbestos exposure have continued to climb. Increasing awareness of the rare cancer has led to the contrasting trends and an expected rise in personal injury lawsuits involving secondary asbestos exposure. “One of the reasons is that we are getting better at diagnosing the disease,” attorney Daniel Wasserberg, who specializes in asbestos litigation, told The Mesothelioma Center at asbestos.com. “Years ago, a woman with classic mesothelioma symptoms, but wi...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
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