AI may help women with ductal hyperplasia avoid surgery
New York City researchers found that an artificial intelligence (AI) algorithm...Read more on AuntMinnie.comRelated Reading: Mammo AI software yields workflow, economic benefits JNCI: Breast screening AI software equals radiologists AI-based CAD software improves breast cancer detection 4 ways AI can improve women's imaging AI can predict breast cancer molecular subtypes on MRI
Background: Invasive breast cancer (IBC) can be categorized into prognostic and predictive molecular subtypes (including luminal breast cancer) using gene expression profiling. Luminal IBC comprises a variety of histological subtypes with varying clinical and pathological features.Summary: IBC of no special subtype is the most common histological subtype in general and likewise within luminal IBC. Classical invasive lobular breast cancer, typically clustering into luminal subgroup, is characterized by discohesive growth and loss of E-cadherin expression. Infrequent, morphologically distinct luminal IBC subtypes are tubular...
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Zakir Hossen, Mohammed Abid Abrar, Sharmin R. Ara, Md. Kamrul Hasan
An imaging technique that combines F-18 FDG PET and MRI was able to pinpoint...Read more on AuntMinnie.comRelated Reading: SNMMI 2020: How nuclear medicine handled COVID-19 SNMMI 2020: Medical students key to the specialty's future PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse Biomarkers on PET, MRI show breast cancer risk
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Jie Zhang, Sujie Zhang, Xiaoyan Li, Fan Zhang, Lei Zhao
Conclusion: The current study clearly demonstrates that the Momordica charantia aryl and seed extracts have the potential to exert its cytotoxic effect on breast cancer cells by a mechanism involving inhibition of EGFR and EGRF related pathways with the induction of apoptosis. The overall finding demonstrates that this plant, especially seed extract, could be a potential source of new anticancer compounds for possible drug development against cancer.
CONCLUSION: None of the six proteins proved to be suitable prognostic factors for OS and DSF in patients with TNBC. PMID: 32266539 [PubMed - indexed for MEDLINE]
CONCLUSION: Knowledge of initiation and growth of tumors with known effects of neo-ATs suggest that intermittent endocrine ATs may achieve the same results as EATs but with improved quality of life and survival because of fewer side effects and better compliance. The challenge for developments of repeated ATs becomes: how short is short enough. PMID: 32472445 [PubMed - indexed for MEDLINE]
Abstract PURPOSE: Few studies have investigated the relationship between vitiligo and risks of various types of cancers, especially those other than skin cancer. Conventional observational studies are susceptible to potential confounders and inverse causation. With a Mendelian randomization approach, we were able to evaluate the causality between vitiligo and different cancer risks. METHODS: 37 vitiligo-related single-nucleotide polymorphisms identified by the published genome-wide association studies were used as instrumental variables in our study. Summary data of individual-level genetic information were o...
CONCLUSIONS: HER2Bi- or EGFRBi-armed CART19 exhibited specific cytotoxicity against multiple HER2+/EGFR+/CD19- tumor targets in overnight and long-term serial killing assays. CART19 showed improved survival and were resistant to exhaustion after prolonged repeated exposure to tumor cells. PMID: 32449004 [PubMed - indexed for MEDLINE]
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