Chest pain, dyspnea and left bundle branch block: the key was in the simplest.
[Chest pain, dyspnea and left bundle branch block: the key was in the simplest]. Aten Primaria. 2019 Mar 09;: Authors: Fabregat-Andrés Ó, Margarit J, Valverde-Navarro AA PMID: 30862387 [PubMed - as supplied by publisher]
In this study, the relationship between P2X7R activation and p38 phosphorylation in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) in the development and maintenance of BTZ-induced neuropathic pain was elucidated. The results showed that BTZ increased mechanical thresholds in rats, accompanied with upregulation of P2X7R expression and p38MAPK phosphorylation, indicating that P2X7R and p38MAPK are key molecules in the development and maintenance of BTZ-induced neuropathic pain. Inhibiting p38MAPK phosphorylation with SB203580 resulted in downregulation of P2X7R expression levels. Inhibition of P2X7R with Brilli...
Publication date: Available online 1 August 2020Source: Journal of the World Federation of OrthodontistsAuthor(s): Khadijah A. Turkistani
Publication date: Available online 9 July 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Hélène Charbonneau, Ségolène Mrozek, Benjamin Pradere, Jean-Nicolas Cornu, Vincent Misrai
The other week, my husband and I were driving home after visiting a beloved family member who is struggling with the excruciating pain and to-the-bone weariness of cancer. As our car lugged down the highway, I thought about the ongoing cruelty of our world: the ravages of disease and war, the current pandemic, the never-ending inhumanity, inequality, and brutality, as well as the general disregard to our earth and the innocent creatures who are clinging to survive on it. (And, yes, I do realize that I’m just as guilty as the masses in spewing out pollution by the simple fact that I drive a car). I held back tears, an...
Publication date: Available online 1 August 2020Source: Journal of Psychiatric ResearchAuthor(s): Sarah F. Allen, Simon Gilbody, Karl Atkin, Christina van der Feltz-Cornelis
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the tr...
We present a case of multiple glomus tumor in the foot of a 41-year-old woman. After several surgical consultations, she had been referred for further surgery including possible ampu-tation, which she declined. Simultaneous multiple excisions of the tumors resulted in complete symptomatic relief. This case confirms that glomus tumors should be considered in a patient with multiple lesions producing ex-cruciating pain. PMID: 32732446 [PubMed - in process]
CONCLUSIONS: 1. The quality of life improved significantly after just six weeks following hip arthroplasty. 2. The results were significantly higher also after 6 months. 3. The functional status of the patients improved significantly at both 6 weeks and 6 months after hip arthroplasty, especially in terms of pain reduction. PMID: 32732444 [PubMed - in process]